Genetic variants associated with female reproductive ageing – potential markers for assessing ovarian function and ovarian stimulation outcome

Premature Ovarian Failure: A Critical Condition in The Reproductive Potential with Various Genetic Causes

Outcome and reproductive function after chemotherapy for ovarian dysgerminoma.

PURPOSE To review the outcome for all patients with ovarian dysgerminoma treated at the M.D. Anderson Cancer Center who received bleomycin, etoposide, and cisplatin (BEP) and to assess the menstrual and reproductive function of those who received conservative treatment. PATIENTS AND METHODS Clinical information was abstracted from the medical record. Patients completed a detailed questionnair...

Genetic variants in telomere‐maintenance genes are associated with ovarian cancer risk and outcome

Most ovarian cancer patients present at an advanced stage with poor prognosis. Telomeres play a critical role in protecting chromosomes stability. The associations of genetic variants in telomere maintenance genes and ovarian cancer risk and outcome are unclear. We genotyped 137 single nucleotide polymorphisms (SNPs) in telomere-maintenance genes in 417 ovarian cancer cases and 417 matched heal...

Genetic variants in the fibroblast growth factor pathway as potential markers of ovarian cancer risk, therapeutic response, and clinical outcome.

BACKGROUND The fibroblast growth factor (FGF) and FGF receptor (FGFR) axis plays a critical role in tumorigenesis, but little is known of its influence in ovarian cancer. We sought to determine the association of genetic variants in the FGF pathway with risk, therapeutic response, and survival of patients with ovarian cancer. METHODS We matched 339 non-Hispanic white ovarian cancer cases with...

Only Female Age, and Not Blood Type, Is Associated with Ovarian Reserve